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Research

Publications

Nishie, W., Jackow, J., Hofmann, S.C., Franzke, C.-W., and Bruckner-Tuderman, L. (2012). Coiled coils ensure the physiological ectodomain shedding of collagen XVII. The Journal of Biological Chemistry 287, 29940–29948.

Wöhrle, F.U., Halbach, S., Aumann, K., Schwemmers, S., Braun, S., Auberger, P., Schramek, D., Penninger, J.M., Laßmann, S., Werner, M., et al. (2012). Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors. Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1–12.

Reinheckel, T., Peters, C., Krüger, A., Turk, B., and Vasiljeva, O. (2012). Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target. Frontiers in Pharmacology 3, 133.

Ortiz-Padilla, C., Gallego-Ortega, D., Browne, B.C., Hochgräfe, F., Caldon, C.E., Lyons, R.J., Croucher, D.R., Rickwood, D., Ormandy, C.J., Brummer, T., et al. (2012). Functional characterization of cancer-associated Gab1 mutations. Oncogene 1–7.

Heinke, J., Kerber, M., Rahner, S., Mnich, L., Lassmann, S., Helbing, T., Werner, M., Patterson, C., Bode, C., and Moser, M. (2012). Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behavior. Oncogene 31, 2919–2930.

Holeiter, G., Bischoff, a, Braun, a C., Huck, B., Erlmann, P., Schmid, S., Herr, R., Brummer, T., and Olayioye, M. a (2012). The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity. Oncogenesis 1, e13.

Franzke, C.-W., Cobzaru, C., Triantafyllopoulou, A., Löffek, S., Horiuchi, K., Threadgill, D.W., Kurz, T., Van Rooijen, N., Bruckner-Tuderman, L., and Blobel, C.P. (2012). Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. The Journal of Experimental Medicine 209, 1105–1119.

Hurskainen, T., Moilanen, J., Sormunen, R., Franzke, C.-W., Soininen, R., Loeffek, S., Huilaja, L., Nuutinen, M., Bruckner-Tuderman, L., Autio-Harmainen, H., et al. (2012). Transmembrane collagen XVII is a novel component of the glomerular filtration barrier. Cell and Tissue Research 348, 579–588.

Gopinathan, A., Denicola, G.M., Frese, K.K., Cook, N., Karreth, F. a, Mayerle, J., Lerch, M.M., Reinheckel, T., and Tuveson, D. a (2012). Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice. Gut 61, 877–884.

Röring, M., Herr, R., Fiala, G.J., Heilmann, K., Braun, S., Eisenhardt, A.E., Halbach, S., Capper, D., Von Deimling, A., Schamel, W.W., et al. (2012). Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling. The EMBO Journal 31, 2629–2647.

Brabletz, T. (2012). To differentiate or not–routes towards metastasis. Nature Reviews Cancer 12, 425–436.

Reipschläger, S., Kubatzky, K., Taromi, S., Burger, M., Orth, J., Aktories, K., and Schmidt, G. (2012). Toxin-induced RhoA activity mediates CCL1-triggered signal transducers and activators of transcription protein signaling. The Journal of Biological Chemistry 287, 11183–11194.

Lassmann, S., and Werner, M. (2012). Predictive pathology in routine diagnostics of solid tumors Histology and. Histol Histopathol 27, 289–296.

Müller, S., Dennemärker, J., and Reinheckel, T. (2012). Specific functions of lysosomal proteases in endocytic and autophagic pathways. Biochimica Et Biophysica Acta 1824, 34–43.

Röring, M., and Brummer, T. (2012). Aberrant B-Raf signaling in human cancer — 10 years from bench to bedside. Critical Reviews in Oncogenesis 17, 97–121.

Qi, W., Huang, X., Neumann-Haefelin, E., Schulze, E., and Baumeister, R. (2012). Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans. PLoS Genetics 8, e1002836.