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Research

Publications

Probst, S., Daza, R., Bader, N., Hummel, J.F., Weiß, M., Tanriver, Y., Hevner, R.F., Arnold, S.J. (2017) A Dual-Fluorescence Reporter in the Eomes Locus for Live Imaging and Medium-Term Lineage Tracing, Genesis 2017 Jun 24. doi: 10.1002/dvg.23043. [Epub ahead of print]

Sulaimanov N, Klose M, Busch H, Boerries M (2017) Understanding the mTOR signaling pathway via mathematical modeling. Wiley Interdisciplinary Reviews: Systems Biology and Medicine e1379. doi: 10.1002/wsbm.1379

Andrlová H, Mastroianni J, Madl J, Kern JS, Melchinger W, Dierbach H, Wernet F, Follo M, Technau-Hafsi K, Has C, Mittapalli VR, Idzko M, Herr R, Brummer T, Ungefroren H, Busch H, Boerries M, Narr A, Ihorst G, Vennin C, Schmitt-Graeff A, Minguet S, Timpson P, Duyster J, Meiss F, Römer W, Zeiser R. (2017) Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression. Oncotarget. 2017 Apr 17. doi: 10.18632/oncotarget.17160. [Epub ahead of print]

Weinberg F, Reischmann N, Fauth L, Taromi S, Mastroianni J, Köhler M, Halbach S, Becker AC, Deng N, Schmitz T, Uhl FM, Herbener N, Riedel B, Beier F, Swarbrick A, Lassmann S, Dengjel J, Zeiser R, Brummer T. The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior. EBioMedicine. 2017 Jun;20:79-97. doi: 10.1016/j.ebiom.2017.04.015.

Kuechlin, S., M. Schoels, K. Slanchev, S. Lassmann, G. Walz and T. A. Yakulov (2017). “EpCAM controls morphogenetic programs during zebrafish pronephros development.” Biochem Biophys Res Commun 487(2): 209-215.

Qi, W., Yan, Y., Pfeifer, D., Donner, V. G. E., Wang, Y., Maier, W. & Baumeister, R. (2017) C. elegans DAF-16/FOXO interacts with TGF-ss/BMP signaling to induce germline tumor formation via mTORC1 activation. PLoS Genet, 13(5), e1006801.

Duteil, D., Tosic, M., Willmann, W., Georgiadi, A., Kanouni, T. and Schüle, R. (2017) Lsd1 prevents age-programed loss of beige adipocytes. Proc. Natl. Acad. Sci. USA, 114(20):5265-5270.

Allan ERO, Campden RI, Ewanchuk BW, Tailor P, Balce DR, McKenna NT, Greene CJ, Warren AL, Reinheckel T, Yates RM. (2017) A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis. J Neuroinflammation. 2017 May 10;14(1):103. doi: 10.1186/s12974-017-0874-x.

Mengwasser J, Babes L, Cordes S, Mertlitz S, Riesner K, Shi Y, McGearey A, Kalupa M, Reinheckel T, Penack O. (2017) Cathepsin E Deficiency Ameliorates Graft-versus-Host Disease and Modifies Dendritic Cell Motility. Front Immunol. 2017 Mar 1;8:203. doi: 10.3389/fimmu.2017.00203. eCollection 2017.

Krebs, A.M., Mitschke, J., Losada, M.L., Schmalhofer, O., Boerries, M., Busch, H., Boettcher, M., Mougiakakos, D., Reichardt, W., Bronsert, P., Brunton, V.G., Pilarsky, C., Winkler, T.H., Brabletz, S., Stemmler, M.P., Brabletz, T. (2017) The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Nat Cell Biol. 19, 518-529.

Ketterer S, Gomez-Auli A, Hillebrand LE, Petrera A, Ketscher A, Reinheckel T (2017) Inherited diseases caused by mutations in cathepsin protease genes. The FEBS Journal. doi: 10.1111/febs.13980

Enderle-Ammour K, Bader M, Ahrens TD, Franke K, Timme S, Csanadi A, Hoeppner J, Kulemann B, Maurer J, Reiss P, Schilling O, Keck T, Brabletz T, Stickeler E, Werner M, Wellner UF, Bronsert P. (2017) Form follows function: Morphological and immunohistological insights into epithelial-mesenchymal transition characteristics of tumor buds. Tumour Biol. 2017 May;39(5):1010428317705501. doi: 10.1177/1010428317705501

Paireder M, Tholen S, Porodko A, Biniossek ML, Mayer B, Novinec M, Schilling O, Mach L (2017) The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B. Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics 1865:444–452. doi: 10.1016/j.bbapap.2017.02.007

Brabletz S, Lasierra Losada M, Schmalhofer O, Mitschke J, Krebs A, Brabletz T, Stemmler MP (2017) Generation and characterization of mice for conditional inactivation of Zeb1. Genesis e23024. doi: 10.1002/dvg.23024

Kuechlin, S., Schoels, M., Slanchev, K., Lassmann, S., Walz, G., and Yakulov, T.A. (2017). EpCAM controls morphogenetic programs during zebrafish pronephros development. Biochem Biophys Res Commun 487(2):209-215.

Ruf S, Heberle AM, Langelaar-Makkinje M, Gelino S, Wilkinson D, Gerbeth C, Schwarz JJ, Holzwarth B, Warscheid B, Meisinger C, van Vugt MATM, Baumeister R, Hansen M, Thedieck K (2017) PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Autophagy 1–20. doi: 10.1080/15548627.2016.1263781