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Research

Publications

Diedrich B, Rigbolt KT, Röring M, Herr R, Kaeser‐Pebernard S, Gretzmeier C, Murphy RF, Brummer T, Dengjel J (2017) Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition. The EMBO Journal e201694732. doi: 10.15252/embj.201694732

Castex J, Willmann D, Kanouni T, Arrigoni L, Li Y, Friedrich M, Schleicher M, Wöhrle S, Pearson M, Kraut N, Méret M, Manke T, Metzger E, Schüle R, Günther T (2017) Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4. Cell Death and Disease 8:e2631. doi: 10.1038/cddis.2017.48

Preca B-T, Bajdak K, Mock K, Lehmann W, Sundararajan V, Bronsert P, Matzge-Ogi A, Orian-Rousseau V, Brabletz S, Brabletz T, Maurer J, Stemmler MP (2017) A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer. Oncotarget. doi: 10.18632/oncotarget.14563

Zahaf NI, Lang AE, Kaiser L, Fichter CD, Lassmann S, McCluskey A, Augspach A, Aktories K, Schmidt G. (2017) Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells. Sci Rep. 2017 Jan 27;7:41252. doi: 10.1038/srep41252.

Jägle S, Dertmann A, Schrempp M, Hecht A (2017) ZEB1 is neither sufficient nor required for epithelial-mesenchymal transition in LS174T colorectal cancer cells. Biochemical and Biophysical Research Communications 482:1226–1232. doi: 10.1016/j.bbrc.2016.12.017

Läppchen T, Tönnesmann R, Eersels J, Meyer PT, Maecke HR, Rylova SN (2017) Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake. PLOS ONE 12:e0170435. doi: 10.1371/journal.pone.0170435

Ahrens TD, Lutz L, Lassmann S, Werner M. (2017) Turning Skyscrapers into Town Houses: Insights into Barrett’s Esophagus. Pathobiology. 2017;84(2):87-98. doi: 10.1159/000447779.

Wolf C, Qian Y, Brooke MA, Kelsell DP, Franzke C-W (2016) ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phosholipase C γ1 and protein kinase C pathways. Scientific Reports 6:39780. doi: 10.1038/srep39780

Taromi S, Kayser G, Catusse J, von Elverfeldt D, Reichardt W, Braun F, Weber WA, Zeiser R, Burger M (2016a) CXCR4 antagonists suppress small cell lung cancer progression. Oncotarget. doi: 10.18632/oncotarget.13238

Strietz J, Stepputtis SS, Preca B-T, Vannier C, Kim MM, Castro DJ, Au Q, Boerries M, Busch H, Aza-Blanc P, Heynen-Genel S, Bronsert P, Kuster B, Kuster B, Stickeler E, Brabletz T, Oshima RG, Maurer J (2016) ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer. Oncotarget. doi: 10.18632/oncotarget.13086

Young AI, Law AM, Castillo L, Chong S, Cullen HD, Koehler M, Herzog S, Brummer T, Lee EF, Fairlie WD, Lucas MC, Herrmann D, Allam A, Timpson P, Watkins DN, Millar EK, O’Toole SA, Gallego-Ortega D, Ormandy CJ, Oakes SR. (2016). MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib. Breast Cancer Res. 2016 Dec 8;18(1):125.

Rupp T, Langlois B, Koczorowska MM, Radwanska A, Sun Z, Hussenet T, Lefebvre O, Murdamoothoo D, Arnold C, Klein A, Biniossek ML, Hyenne V, Naudin E, Velazquez-Quesada I, Schilling O, Van Obberghen-Schilling E, Orend G (2016) Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling. Cell Reports 17:2607–2619. doi: 10.1016/j.celrep.2016.11.012

Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, Müller A-L, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ, Lienkamp SS (2016) Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors. Nature Cell Biology 18:1269–1280. doi: 10.1038/ncb3437

Löffek S, Franzke C-W, Helfrich I (2016) Tension in Cancer. International Journal of Molecular Sciences 17:1910. doi: 10.3390/ijms17111910

Schnappauf O, Beyes S, Dertmann A, Freihen V, Frey P, Jägle S, Rose K, Michoel T, Grosschedl R, Hecht A (2016) Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing. Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms 1859:1353–1367. doi: 10.1016/j.bbagrm.2016.08.002

Sigloch FC, Knopf JD, Weißer J, Gomez-Auli A, Biniossek ML, Petrera A, Schilling O (2016) Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research 1863:2700–2709. doi: 10.1016/j.bbamcr.2016.08.005