Call us +49 (0)761 / 203 9600



Duteil, D., Tosic, M., Lausecker, F., Nenseth, H. Z., Müller, J. M., Urban, S., Willmann, W., Petroll, K., Messaddeq, N., Arrigoni, L., Manke, T., Kornfeld, J.-W., Brüning, J.C., Zagoriy, V., Meret, M., Dengjel, J., Kanouni, T. and Schüle, R. (2016) Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue. Cell Rep. 17, 1008-1021.

Duteil D, Tosic M, Lausecker F, Nenseth HZ, Müller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld J-W, Brüning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Schüle R (2016) Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue. Cell Reports 17:1008–1021. doi: 10.1016/j.celrep.2016.09.053

Shahinian JH, Fuellgraf H, Tholen S, Mastroianni J, Knopf JD, Kuehs M, Mayer B, Schlimpert M, Kulemann B, Kuesters S, Hoeppner J, Wellner UF, Werner M, Hopt UT, Zeiser R, Bronsert P, Schilling O (2016) Pregnancy Specific β-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival. Journal of Cancer 7:2018–2027. doi: 10.7150/jca.15864

Nilse L, Avci D, Heisterkamp P, Serang O, Lemberg MK, Schilling O (2016) Yeast membrane proteomics using leucine metabolic labelling: Bioinformatic data processing and exemplary application to the ER-intramembrane protease Ypf1. Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics 1864:1363–1371. doi: 10.1016/j.bbapap.2016.07.002

Taromi S, Kayser G, von Elverfeldt D, Reichardt W, Braun F, Weber WA, Zeiser R, Burger M (2016b) An orthotopic mouse model of small cell lung cancer reflects the clinical course in patients. Clinical & Experimental Metastasis 33:651–660. doi: 10.1007/s10585-016-9808-8

Ngoune R, Peters A, von Elverfeldt D, Winkler K, Pütz G (2016) Accumulating nanoparticles by EPR: A route of no return. Journal of Controlled Release 238:58–70. doi: 10.1016/j.jconrel.2016.07.028

Morera L, Roatsch M, Fürst MCD, Hoffmann I, Senger J, Hau M, Franz H, Schüle R, Heinrich MR, Jung M (2016) 4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A. ChemMedChem 11:2063–2083. doi: 10.1002/cmdc.201600218

Slynko I, Schmidtkunz K, Rumpf T, Klaeger S, Heinzlmeir S, Najar A, Metzger E, Kuster B, Schüle R, Jung M, Sippl W (2016) Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing. ChemMedChem 11:2084–2094. doi: 10.1002/cmdc.201600284

Hillebrand LE, Bengsch F, Hochrein J, Hülsdünker J, Bender J, Follo M, Busch H, Boerries M, Reinheckel T (2016) Proteolysis-a characteristic of tumor-initiating cells in murine metastatic breast cancer. Oncotarget. doi: 10.18632/oncotarget.11309

Petrera A, Kern U, Linz D, Gomez-Auli A, Hohl M, Gassenhuber J, Sadowski T, Schilling O (2016b) Proteomic Profiling of Cardiomyocyte-Specific Cathepsin A Overexpression Links Cathepsin A to the Oxidative Stress Response. Journal of Proteome Research 15:3188–3195. doi: 10.1021/acs.jproteome.6b00413

Robaa D, Wagner T, Luise C, Carlino L, McMillan J, Flaig R, Schüle R, Jung M, Sippl W (2016) Identification and Structure-Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1. ChemMedChem 11:2327–2338. doi: 10.1002/cmdc.201600362

Roatsch M, Robaa D, Pippel M, Nettleship JE, Reddivari Y, Bird LE, Hoffmann I, Franz H, Owens RJ, Schüle R, Flaig R, Sippl W, Jung M (2016) Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases. Future Medicinal Chemistry 8:1553–1571. doi: 10.4155/fmc.15.188

Röst HL, Sachsenberg T, Aiche S, Bielow C, Weisser H, Aicheler F, Andreotti S, Ehrlich H-C, Gutenbrunner P, Kenar E, Liang X, Nahnsen S, Nilse L, Pfeuffer J, Rosenberger G, Rurik M, Schmitt U, Veit J, Walzer M, Wojnar D, Wolski WE, Schilling O, Choudhary JS, Malmström L, Aebersold R, Reinert K, Kohlbacher O (2016) OpenMS: a flexible open-source software platform for mass spectrometry data analysis. Nature Methods 13:741–748. doi: 10.1038/nmeth.3959

Fascellaro G, Petrera A, Lai ZW, Nanni P, Grossmann J, Burger S, Biniossek ML, Gomez-Auli A, Schilling O, Imkamp F (2016) Comprehensive Proteomic Analysis of Nitrogen-Starved Mycobacterium smegmatis Δ pup Reveals the Impact of Pupylation on Nitrogen Stress Response. Journal of Proteome Research 15:2812–2825. doi: 10.1021/acs.jproteome.6b00378

Paireder M, Mehofer U, Tholen S, Porodko A, Schähs P, Maresch D, Biniossek ML, van der Hoorn RAL, Lenarcic B, Novinec M, Schilling O, Mach L (2016) The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity. Archives of Biochemistry and Biophysics 603:110–117. doi: 10.1016/

Rylova SN, Waser B, Del Pozzo L, Tonnesmann R, Mansi R, Meyer PT, Reubi JC, Maecke HR (2016) Approaches to Improve the Pharmacokinetics of Radiolabeled Glucagon-Like Peptide-1 Receptor Ligands Using Antagonistic Tracers. Journal of Nuclear Medicine 57:1282–1288. doi: 10.2967/jnumed.115.168948