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Research

Publications

Biniossek ML, Niemer M, Maksimchuk K, Mayer B, Fuchs J, Huesgen PF, McCafferty DG, Turk B, Fritz G, Mayer J, Haecker G, Mach L, Schilling O (2016) Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics. Mol Cell Proteomics [Epub ahead of print]

Lai ZW, Weisser J, Nilse L, Costa F, Keller E, Tholen M, Kizhakkedathu JN, Biniossek M, Bronsert P, Schilling O (2016b) Formalin-Fixed, Paraffin-Embedded Tissues as a Robust Source for the Profiling of Native and Protease-Generated Protein Amino Termini. Mol Cell Proteomics [Epub ahead of print]

Petrera A, Gassenhuber J, Ruf S, Gunasekaran D, Esser J, Shahinian JH, Hübschle T, Rütten H, Sadowski T, Schilling O (2016a) Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels. Journal of Translational Medicine. doi: 10.1186/s12967-016-0907-8

Basilicata MF, Frank M, Solter D, Brabletz T, Stemmler MP (2016) Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation. Scientific Reports 6:26562. doi: 10.1038/srep26562

Wagner T, Greschik H, Burgahn T, Schmidtkunz K, Schott AK, McMillan J, Baranauskiene L, Xiong Y, Fedorov O, Jin J, Oppermann U, Matulis D, Schüle R, Jung M (2016) Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform. Nucleic Acids Res Feb 17. pii: gkw089. [Epub ahead of print]

Tholen S, Wolf C, Mayer B, Knopf JD, Löffek S, Qian Y, Kizhakkedathu JN, Biniossek ML, Franzke C-W, Schilling O (2016) Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations. Journal of Proteome Research 15:1402–1417. doi: 10.1021/acs.jproteome.5b00691

Fluhr S, Boerries M, Busch H, Symeonidi A, Witte T, Lipka DB, Mücke O, Nöllke P, Krombholz CF, Niemeyer CM, Plass C, Flotho C (2016) CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia. Clinical Epigenetics. doi: 10.1186/s13148-016-0216-3

Eisenhardt AE, Sprenger A, Röring M, Herr R, Weinberg F, Köhler M, Braun S, Orth J, Diedrich B, Lanner U, Tscherwinski N, Schuster S, Dumaz N, Schmidt E, Baumeister R, Schlosser A, Dengjel J, Brummer T (2016) Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Oncotarget, Mar 28. doi: 10.18632/oncotarget.8427. [Epub ahead of print]

Jacków J, Löffek S, Nyström A, Bruckner-Tuderman L, Franzke C-W (2016) Collagen XVII Shedding Suppresses Re-Epithelialization by Directing Keratinocyte Migration and Dampening mTOR Signaling. Journal of Investigative Dermatology 136:1031–1041. doi: 10.1016/j.jid.2016.01.012

Lai ZW, Bolm L, Fuellgraf H, Biniossek ML, Makowiec F, Hopt UT, Werner M, Keck T, Bausch D, Sorio C, Scarpa A, Schilling O, Bronsert P, Wellner UF (2016a) Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses. BMC Cancer 16: 195

Gomez-Auli A, Hillebrand LE, Biniossek ML, Peters C, Reinheckel T, Schilling O (2016) Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers. Biochimie 122: 88-98

Ketscher A, Ketterer S, Dollwet-Mack S, Reif U, Reinheckel T (2016) Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10. Biochimie 122: 219-26

Spohn L, Fichter C, Werner M, Lassmann S (2016) Subcellular localization of EGFR in esophageal carcinoma cell lines. Journal of Cell Communication and Signaling 10:41–47. doi: 10.1007/s12079-015-0308-4

Jackow J, Schlosser A, Sormunen R, Nystrom A, Sitaru C, Tasanen K, Bruckner-Tuderman L, Franzke CW (2016b) Generation of a Functional Non-Shedding Collagen XVII Mouse Model: Relevance of Collagen XVII Shedding in Wound Healing. J Invest Dermatol 136: 516-25

Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, Herr R, Brabletz S, Stemmler MP, Brabletz T (2016) ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nat Commun 7: 10498

Metzger E, Willmann D, McMillan J, Forne I, Metzger P, Gerhardt S, Petroll K, von Maessenhausen A, Urban S, Schott AK, Espejo A, Eberlin A, Wohlwend D, Schule KM, Schleicher M, Perner S, Bedford MT, Jung M, Dengjel J, Flaig R, Imhof A, Einsle O, Schüle R. (2016) Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation. Nat Struct Mol Biol 23: 132-9